|
rs9509
|
|
Congenital arteriovenous malformation
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs9509 polymorphism of MMP-9 is associated with risk of hemorrhage in brain arteriovenous malformations.
|
22796276 |
2012 |
|
rs9509
|
|
Arteriovenous hemangioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs9509 polymorphism of MMP-9 is associated with risk of hemorrhage in brain arteriovenous malformations.
|
22796276 |
2012 |
|
rs8125581
|
|
Aortic Aneurysm, Abdominal
|
|
0.010 |
GeneticVariation
|
BEFREE |
Analyses identified MMP-9 p-2502 single nucleotide polymorphism (odds ratio [OR], 0.54; 95% confidence interval [CI], 0.31-0.94; P = .029) as a significant confound discriminating between control vs slow-growth AAA, MMP-9 D165N (OR, 0.49; 95% CI, 0.26-0.95; P = .035) and LRP1 (OR, 4.99; 95% CI, 1.13-22.1; P = .034) between control vs aggressive-growth AAAs, and methyltetrahydrofolate reductase (OR, 2.99; 95% CI, 1.01-8.86; P = .048), MMP-9 p-2502 (OR, 2.19; 95% CI, 1.05-4.58; P = .037), and LRP1 (OR, 4.96; 95% CI, 1.03-23.9; P = .046) as the statistically significant confounds distinguishing slow-growth AAAs vs aggressive-growth AAAs.
|
24801553 |
2014 |
|
rs80077409
|
|
Lupus Erythematosus, Systemic
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study for the first time not only suggests that MMP-9 -C1562 T and MMP-2 -G1575A alleles synergistically increase the risk of SLE but also high serum levels of MDA, neopterin, and circulatory levels of MMP-2 and lower MMP-9 in SLE patients.
|
25416694 |
2015 |
|
rs79845319
|
|
Prolapsed lumbar disc
|
|
0.010 |
GeneticVariation
|
BEFREE |
The SNP rs17576 was found to be significantly associated with susceptibility to LDH (OR = 0.77, p = 0.0002), which was also confirmed by haplotype-based analyses (rs79845319-rs17576-rs45437897, global p < 0.001).
|
30289281 |
2018 |
|
rs45437897
|
|
Prolapsed lumbar disc
|
|
0.010 |
GeneticVariation
|
BEFREE |
The SNP rs17576 was found to be significantly associated with susceptibility to LDH (OR = 0.77, p = 0.0002), which was also confirmed by haplotype-based analyses (rs79845319-rs17576-rs45437897, global p < 0.001).
|
30289281 |
2018 |
|
rs41529445
|
|
Influenza due to Influenza A virus subtype H1N1
|
|
0.700 |
GeneticVariation
|
GWASCAT |
No Major Host Genetic Risk Factor Contributed to A(H1N1)2009 Influenza Severity.
|
26379185 |
2015 |
|
rs3918270
|
|
Serum albumin measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
|
22286219 |
2012 |
|
rs3918261
|
|
Serum albumin measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
|
22286219 |
2012 |
|
rs3918256
|
|
Ptosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Of these, two were associated with advanced prolapse: 1) rs3918253 (adjusted odds ratio [OR] 0.64, 95% confidence interval [CI] 0.41-1.0, P=.05); and 2) rs3918256 (adjusted OR 0.64, 95% CI 0.41-1.01, P=.05).
|
22914468 |
2012 |
|
rs3918254
|
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
Additionally, the haplotype "AGTCA" constructed by rs3740938, rs2012390, rs1940475, rs11225394, and rs11225395 and the haplotype "CCG" constructed by rs3918249, rs3918254 and rs3787268 were associated with increased risk of BC (P < 0.05).
|
30194384 |
2018 |
|
rs3918254
|
|
Psoriasis vulgaris
|
|
0.010 |
GeneticVariation
|
BEFREE |
Similar results were found in further subgroup analysis based on gender, age of onset, family history, and serum MMP-9 levels, except that a protective effect of psoriasis vulgaris was detected among female subjects with the CT genotype of rs3918254 (OR=0.47, 95% CI=0.23-0.96, P=0.038), but this association did not survive after Bonferroni correction (P(adj)=0.076).
|
26554609 |
2015 |
|
rs3918254
|
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Additionally, the haplotype "AGTCA" constructed by rs3740938, rs2012390, rs1940475, rs11225394, and rs11225395 and the haplotype "CCG" constructed by rs3918249, rs3918254 and rs3787268 were associated with increased risk of BC (P < 0.05).
|
30194384 |
2018 |
|
rs3918254
|
|
Henoch-Schonlein purpura nephritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
These observations suggest that the rs17576 and rs3918254 polymorphisms of MMP9 are associated with HSPN.
|
27323137 |
2016 |
|
rs3918253
|
|
Chronic Obstructive Airway Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
rs243864 (OR: 7.44; 95% CI: 3.62-15.26) and rs11646643 (OR: 1.58; 95% CI: 1.07-2.34) of the MMP-2 gene and rs3918253 (OR: 1.72; 95% CI: 1.08-2.71) of the MMP-9 gene, were associated with the risk of COPD.
|
26439471 |
2015 |
|
rs3918253
|
|
Ptosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Of these, two were associated with advanced prolapse: 1) rs3918253 (adjusted odds ratio [OR] 0.64, 95% confidence interval [CI] 0.41-1.0, P=.05); and 2) rs3918256 (adjusted OR 0.64, 95% CI 0.41-1.01, P=.05).
|
22914468 |
2012 |
|
rs3918252
|
|
Tumor Cell Invasion
|
|
0.010 |
GeneticVariation
|
BEFREE |
Zymographic MMP-2 and MMP-9 production, MMP-9 activity and invasion through matrigel in vitro were significantly less in sgk1(-/-) than in sgk1(+/+)macrophages and in control plasmid-transfected or inactive (K127N)SGK1-transfected than in constitutively active (S422D)SGK1-transfected THP-1 cells.
|
25614279 |
2015 |
|
rs3918249
|
|
Glaucoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Significant associations were only found between MMP-9 rs17576 G > A polymorphism (GA vs. GG: OR = 0.80, 95%CI = 0.67-0.97, P = 0.02, I<sup>2</sup> = 0%), MMP-9 rs3918249 C > T polymorphism (TT vs. CC + CT: OR = 0.71, 95%CI = 0.51-0.98, P = 0.04, I<sup>2</sup> = 0%) and glaucoma risk in the general population.
|
28431514 |
2017 |
|
rs3918249
|
|
Angle Closure Glaucoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
This study demonstrates an association between MMP9 SNPs rs3918249 and rs17576 and PACG in the Australian population, suggesting MMP9 may be involved in the pathogenesis of this blinding disease.
|
21655354 |
2011 |
|
rs3918249
|
|
Primary angle-closure glaucoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
This study demonstrates an association between MMP9 SNPs rs3918249 and rs17576 and PACG in the Australian population, suggesting MMP9 may be involved in the pathogenesis of this blinding disease.
|
21655354 |
2011 |
|
rs3918249
|
|
Angle Closure Glaucoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Significant heterogeneity between non-Chinese and Chinese datasets precluded overall meta-analysis for rs17576 and rs3918249 (Q = 0.001 and 0.04 respectively). rs17577 was nominally associated with PACG in one Caucasian study (OR = 1.71, P = 0.02), but not in 3 Chinese studies including our study (ORs = 1.20, P = 0.07).
|
27272641 |
2016 |
|
rs3918249
|
|
Primary angle-closure glaucoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Significant heterogeneity between non-Chinese and Chinese datasets precluded overall meta-analysis for rs17576 and rs3918249 (Q = 0.001 and 0.04 respectively). rs17577 was nominally associated with PACG in one Caucasian study (OR = 1.71, P = 0.02), but not in 3 Chinese studies including our study (ORs = 1.20, P = 0.07).
|
27272641 |
2016 |
|
rs3918249
|
|
Glaucoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The rs3918249 polymorphism was also associated with a decreased risk of glaucoma, especially for Caucasian patients.
|
26872021 |
2016 |
|
rs3918249
|
|
Asthma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The SNP rs3918249 exhibited a female gender-dependent association with asthma (OR=1.66, 95% CI 1.14-2.43, P=0.007).
|
23639553 |
2013 |
|
rs3918249
|
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Additionally, the haplotype "AGTCA" constructed by rs3740938, rs2012390, rs1940475, rs11225394, and rs11225395 and the haplotype "CCG" constructed by rs3918249, rs3918254 and rs3787268 were associated with increased risk of BC (P < 0.05).
|
30194384 |
2018 |